HYDRA SCZ2

This is the dimension/subtype 2 (SCZ2) of SCZ defined by the HYDRA model using brain imaging data from PHENOM, where SCZ2 shows increased volumes of the putamen and pallidum.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA SCZ2 derived from brain MRI data using UK Biobank.

Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press).