HYDRA SCZ1

This is the dimension/subtype 1 (SCZ1) of SCZ defined by the HYDRA model using brain imaging data from PHENOM, where SCZ1 shows a widespread pattern of reduced brain volumes.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA SCZ1 derived from brain MRI data using UK Biobank.

* Wen, J.. Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. (2025) Nature Biomedical Engineering . Link