HYDRA LLD2
This is the dimension/subtype 2 (LLD2) of late-life depression (LLD)
defined by the HYDRA model using brain imaging data from iSTAGING,
where LLD2 was associated with cortical atrophy (e.g., insula).
QQ plot
Manhattan plot
Summary Statistics
Data: GWAS summary statistics and pre-trained AI models for HYDRA LLD2
derived from brain MRI data using UK Biobank.
Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y.,
Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and
Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect
Disease Heterogeneity and Similarity of Four Brain Disorders. Nature
Biomedical Engineering (in press).
Citation: Wen, J., Fu, C.H., Tosun, D., Veturi, Y.,
Yang, Z., Abdulkadir, A., Mamourian, E., Srinivasan, D., Singh, A.
and Nawani, H., 2022. Characterizing heterogeneity in neuroimaging,
cognition, clinical symptoms, and genetics among patients with
late-life depression. JAMA psychiatry, 79(5), pp.464-474.
