MEDICINE

HYDRA LLD2

This is the dimension/subtype 2 (LLD2) of late-life depression (LLD) defined by the HYDRA model using brain imaging data from iSTAGING, where LLD2 was associated with cortical atrophy (e.g., insula).

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA LLD2 derived from brain MRI data using UK Biobank.

Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press).

Citation: Wen, J., Fu, C.H., Tosun, D., Veturi, Y., Yang, Z., Abdulkadir, A., Mamourian, E., Srinivasan, D., Singh, A. and Nawani, H., 2022. Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression. JAMA psychiatry, 79(5), pp.464-474.

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