MEDICINE

HYDRA LLD1

This is the dimension/subtype 1 (LLD1) of late-life depression (LLD) defined by the HYDRA model using brain imaging data from iSTAGING, where LLD1 was associated with larger brain volume in subcortical structures.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA LLD1 derived from brain MRI data using UK Biobank.

Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press).

Citation: Wen, J., Fu, C.H., Tosun, D., Veturi, Y., Yang, Z., Abdulkadir, A., Mamourian, E., Srinivasan, D., Singh, A. and Nawani, H., 2022. Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression. JAMA psychiatry, 79(5), pp.464-474.

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