HYDRA ASD3

This is the dimension/subtype 3 (ASD3) of ASD defined by the HYDRA model using brain imaging data from ABIDE, where ASD3 (Typical ASD) was distinguished by enlarged cortical volumes, high nonverbal cognitive performance, and biological pathways implicating brain development and abnormal apoptosis.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA ASD3 derived from brain MRI data using UK Biobank.

Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press).