HYDRA ASD2

This is the dimension/subtype 2 (ASD2) of ASD defined by the HYDRA model using brain imaging data from ABIDE, where ASD2 (schizophrenialike) was characterized by enlarged subcortical volumes, antipsychotic medication use.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA ASD2 derived from brain MRI data using UK Biobank.

Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press).