HYDRA ASD1

This is the dimension/subtype 1 (ASD1) of ASD defined by the HYDRA model using brain imaging data from ABIDE, where ASD1 (aginglike) was associated with smaller brain volume, lower cognitive function, and aging-related genetic variants (FOXO3 gene).

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for HYDRA ASD1 derived from brain MRI data using UK Biobank.

Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press).