MEDICINE

Surreal-GAN Aging4

This is the dimension/subtype 4 (Aging4) of brain aging defined by the Surreal-GAN model using brain imaging data from the iSTAGING consortium, where Aging4 is distinguished by diffuse cortical atrophy in medial and lateral frontal regions, as well as superior parietal and occipital regions.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics for Surreal-GAN Aging4 derived from brain MRI data using UK Biobank.

Citation: Yang, Z., Wen, J. (Co-supervision & Genetic analyses), Erus, G., Melhem, R., Mamourian, E., Cui, Y., Srinivasan, D., Abdulkadir, A., Parmpi, P. and Wittfeld, K., 2023. Brain aging patterns in a large and diverse cohort of 49,482 individuals. Nature Medicine .

Citation: Yang, Z., Wen, J. and Davatzikos, C., 2023. Surreal-GAN: Semi-Supervised Representation Learning via GAN for uncovering heterogeneous disease-related imaging patterns. ICLR.

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