Surreal-GAN Aging3
This is the dimension/subtype 3 (Aging3) of brain aging defined by the Surreal-GAN model using brain imaging data from the iSTAGING consortium, where Aging3 indicates the severity of parieto-temporal atrophy, including that in middle temporal gyrus, angular gyrus, and middle occipital gyrus.
QQ plot
Manhattan plot
Summary Statistics
Data: GWAS summary statistics for Surreal-GAN Aging3 derived from brain MRI data using UK Biobank.
Citation: Yang, Z., Wen, J. (Co-supervision & Genetic analyses), Erus, G., Melhem, R., Mamourian, E., Cui, Y., Srinivasan, D., Abdulkadir, A., Parmpi, P. and Wittfeld, K., 2023. Brain aging patterns in a large and diverse cohort of 49,482 individuals. Nature Medicine .
Citation: Yang, Z., Wen, J. and Davatzikos, C., 2023. Surreal-GAN: Semi-Supervised Representation Learning via GAN for uncovering heterogeneous disease-related imaging patterns. ICLR.