MEDICINE

Surreal-GAN Aging2

This is the dimension/subtype 2 (Aging2) of brain aging defined by the Surreal-GAN model using brain imaging data from the iSTAGING consortium, where Aging2 was characterized by focal medial temporal lobe (MTL) atrophy.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for Surreal-GAN Aging2 derived from brain MRI data using UK Biobank.

Citation: Yang, Z., Wen, J. (Co-supervision & Genetic analyses), Erus, G., Melhem, R., Mamourian, E., Cui, Y., Srinivasan, D., Abdulkadir, A., Parmpi, P. and Wittfeld, K., 2023. Brain aging patterns in a large and diverse cohort of 49,482 individuals. Nature Medicine .

Citation: Yang, Z., Wen, J. and Davatzikos, C., 2023. Surreal-GAN: Semi-Supervised Representation Learning via GAN for uncovering heterogeneous disease-related imaging patterns. ICLR.

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