Smile-GAN Aging2

This is the dimension/subtype 2 (Aging2) of brain aging defined by the Smile-GAN model using brain imaging data from the iSTAGING consortium, where Aging2 was associated with hypertension, WMH, and vascular disease–related genetic variants and was enriched for Aβ positivity (ages ≥65 years) and apolipoprotein E (APOE) ε4 carriers.

QQ plot

Manhattan plot

Summary Statistics

Data: GWAS summary statistics and pre-trained AI models for Smile-GAN Aging2 derived from brain MRI data using UK Biobank.