Surreal-GAN AD2
This is the dimension/subtype 2 (AD2) of AD defined by the Surreal-GAN model using brain imaging data, where AD2 shows focal medial temporal and hippocampus brain atrophy. The model was trained and cross-validated on ADNI and then applied to UK Biobank.
QQ plot
Manhattan plot
Summary Statistics
Data: GWAS summary statistics and pre-trained AI models for Surreal-GAN AD2 derived from brain MRI data using UK Biobank.
Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect Disease Heterogeneity and Similarity of Four Brain Disorders. Nature Biomedical Engineering (in press)
Citation: Wen, J., Yang, Z., Nasrallah, I.M., Cui, Y., Erus, G., Srinivasan, D., Abdulkadir, A., Mamourian, E., Hwang, G. and Singh, A., 2024. Genetic and Clinical Correlates of Two Neuroanatomical AI Dimensions in the Alzheimer's Disease Continuum Translational Psychiatry.
Citation: Yang, Z., Wen, J. and Davatzikos, C., 2023. Surreal-GAN: Semi-Supervised Representation Learning via GAN for uncovering heterogeneous disease-related imaging patterns. ICLR.
