Surreal-GAN AD1
This is the dimension/subtype 1 (AD1) of AD defined by the Surreal-GAN
model using brain imaging data, where AD1 shows diffuse brain atrophy.
The model was trained and cross-validated on ADNI and then applied to
UK Biobank.
QQ plot
Manhattan plot
Summary Statistics
Data: GWAS summary statistics and pre-trained AI models for Surreal-GAN
AD1 derived from brain MRI data using UK Biobank.
Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y.,
Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and
Nasrallah, I., 2024. Nine Neuroimaging-AI Endophenotypes Dissect
Disease Heterogeneity and Similarity of Four Brain Disorders. Nature
Biomedical Engineering (in press)
Citation: Wen, J., Yang, Z., Nasrallah, I.M., Cui,
Y., Erus, G., Srinivasan, D., Abdulkadir, A., Mamourian, E., Hwang,
G. and Singh, A., 2024. Genetic and Clinical Correlates of Two
Neuroanatomical AI Dimensions in the Alzheimer's Disease Continuum.
Translational Psychiatry.
Citation: Yang, Z., Wen, J. and Davatzikos, C.,
2023. Surreal-GAN: Semi-Supervised Representation Learning via GAN
for uncovering heterogeneous disease-related imaging patterns. ICLR.
