Surreal-GAN AD1
This is the dimension/subtype 1 (AD1) of AD defined by the Surreal-GAN model using brain imaging data, where AD1 shows diffuse brain atrophy. The model was trained and cross-validated on ADNI and then applied to UK Biobank.
QQ plot
Manhattan plot
Summary Statistics
Data: GWAS summary statistics for Surreal-GAN AD1 derived from brain MRI data using UK Biobank.
Citation: Wen, J., Tian, Y.E., Yang, Z., Cui, Y., Erus, G., Hwang, G., Varol, E., Boquet-Pujadas, A., Chand, G.B. and Nasrallah, I., 2023. Neuroimaging-AI Endophenotypes of Brain Diseases in the General Population: Towards a Dimensional System of Vulnerability (under revision).
Citation: Wen, J., Yang, Z., Nasrallah, I.M., Cui, Y., Erus, G., Srinivasan, D., Abdulkadir, A., Mamourian, E., Hwang, G. and Singh, A., 2024. Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer’s Disease (under revision).
Citation: Yang, Z., Wen, J. and Davatzikos, C., 2023. Surreal-GAN: Semi-Supervised Representation Learning via GAN for uncovering heterogeneous disease-related imaging patterns. ICLR.
